
Mark Edward Humphrey, MD, MPH
Family Medicine
Highlights
Age Groups Seen
- Infants and Toddlers
- Children 2-4
- Children 5 and up
- Teens
- Adults
- Adults 65 and up
Languages
- English
Gender
MaleAbout Mark Edward Humphrey
Mark E. Humphrey, MD, MPH, is a board-certified family medicine physician and medical director for the Prisma Health Family Medicine Center. Prior to joining Prisma Health, he served as a medical and preventive medicine officer with the U.S. Navy, where he completed a humanitarian tour to the South Pacific.
Dr. Humphrey received his medical degree from the Boonshoft School of Medicine at Wright State University in Dayton, Ohio, and completed his family medicine residency at the University of Louisville community program in Glasgow, Kentucky. With an interest in global health and health care policy, Humphrey then completed a preventive medicine residency and a master's degree in public health at Johns Hopkins Bloomberg School of Public Health in Baltimore. He is particularly interested in population-based quality improvement, community medicine, health care policy and global health.
Video
Locations
- Prisma Health Family Medicine – Colonial Dr.
- 3209 Colonial Drive, Columbia, SC 29203
- Get Directions
- phone: 803-434-6113
- fax: 803-434-7231
- Prisma Health Mobile Health Clinic – Midlands
- 1333 Taylor Street, Suite 3H, Columbia, SC 29201
- Get Directions
- phone: 803-296-3726
- fax: 803-296-3460
- Prisma Health Travel Clinic – Columbia
- 3209 Colonial Drive, Columbia, SC 29203
- Get Directions
- phone: 803-434-2233
- fax: 803-434-7231
- Prisma Health Mobile Health Clinic – Midlands
- 1501 Sumter Street, Columbia, SC 29201
- Get Directions
- phone: 803-296-3726
- fax: 803-296-3460
Expertise
Education
- Residency: Johns Hopkins Bloomberg School of Public Health, Preventive Medicine
- Medical School: Wright State University
- Residency: University of Louisville-Glasgow, Family Medicine
Board Certifications
- Family Medicine: American Board of Family Medicine
- Public Health and General Preventive Medicine: American Board of Preventive Medicine
Insurance
- Absolute Total Care - Ambetter
- Absolute Total Care (Centene)
- Aetna
- Aetna Medicare
- Allwell Medicare - Absolute Total Care
- BCBS
- BCBS Blue Essentials
- BCBS PPC
- BCBSSC Blue Reedy Exchange Product (Upstate)
- BCBSSC State Health Plan (PEBA)
- BlueChoice Health Plan
- BlueChoice Medicaid - Healthy Blue
- BlueChoiceMyChoice Advantage
- Carelon Behavioral Health
- Cigna
- Cigna Medicare
- Companion Benefit Alternatives
- CorVel Workers Compensation
- Evernorth Behavioral Health
- FirstHealth (Aetna)
- Healthy Connections
- Humana - Healthy Horizons
- Humana Choice Care
- Humana Medicare
- Liberty Advantage
- Logistics Health
- Magellan
- MedCost
- Medicare (Traditional Fee-for-Service)
- Molina
- Molina Medicaid
- Multiplan/PHCS
- NHC Advantage
- Optum Behavioral Health
- Promise Health Plan
- SC Medicaid Healthy Connections
- Select Health Medicare
- Select Heath (First Choice)
- Spectera
- TriCare
- UnitedHealthcare Medicare Advantage
- Veterans Affairs Community Care Network - VACCN
- Wellcare (Centene)
Ratings & Reviews
4.9 out of 5
158 ratings, 39 reviewsThe Patient Satisfaction Rating is derived from patient surveys based on the likelihood to recommend this provider’s office.
- 5 out of 5 starsReviewed on 2/28/2026
To definitely listen to us while we explain our reasons why we are feeling not well.
- 5 out of 5 starsReviewed on 2/25/2026
Yes, hi. Yes, my Dr. Humphrey is very, very good. I trust in him 100%. Definitely don't like to see anyone else but him. Very knowledgeable, understanding. He's a very good, God-fearing man. Thank you.
- 4 out of 5 starsReviewed on 2/20/2026
Dr sent a prescription, pharmacy wouldn't fill, said required preauthorization. They faxed something to office for Dr to complete, and I called and left a message on nurse line. This was two days ago and I still have not gotten any response from office and have not been able to fill prescription that I really need.
- 5 out of 5 starsReviewed on 2/16/2026
Everything was great
- 5 out of 5 starsReviewed on 2/3/2026
Everything went well!!!,and i'm doing much better,since my last visit.
- 5 out of 5 starsReviewed on 1/9/2026
The nurse was so good. Humphrey knows my needs
- 5 out of 5 starsReviewed on 12/26/2025
My visit with Dr. Humphrey is always the best,he takes care of me!!!!
- 5 out of 5 starsReviewed on 12/18/2025
Everything was great...
- 5 out of 5 starsReviewed on 12/19/2025
Yes, Colonial Family Medicine Prisma Health is a good teaching facility. They're very respectful. I believe that they know their jobs quite well. Their practice is important to the patient as they seem to put you 100% at all times. Mark Humphreys, Dr. Mark Humphreys is a grand doctor. I respect him. He respects me and I feel very comfortable with his service. And I'm always allowing him to use his teaching techniques to his residents, doctors. They're doing a great job.
- 5 out of 5 starsReviewed on 12/18/2025
Everything went great!
- 5 out of 5 starsReviewed on 12/5/2025
Everyone was very nice including the student doctor!
- 5 out of 5 starsReviewed on 11/24/2025
I don't know of anything different that could of taken place. I was treated with the most respect and politeness. It's like they're apart of my family.
- 5 out of 5 starsReviewed on 11/23/2025
My visit was excellent
- 5 out of 5 starsReviewed on 11/8/2025
Everything was great! Great care always!
- 5 out of 5 starsReviewed on 11/7/2025
Some of the Referrals took very long time to Response. To phone a referal dept to follow up she hardly answer the calls. If she does she is not helpful.
- 5 out of 5 starsReviewed on 10/14/2025
Every I have a visit I am treated very well
- 5 out of 5 starsReviewed on 10/2/2025
Everything was great! Dr. Humphrey is a wise and great Doctor. The phlebotomist that drew my blood is great, too. I didn't even feel the needle go in. The staff at the front desk is always kind, and even the security guard was kind. (Smile)
- 5 out of 5 starsReviewed on 10/2/2025
Nothing. Keep up the good work.
- 5 out of 5 starsReviewed on 9/28/2025
Can't think of anything that could have been better.
- 5 out of 5 starsReviewed on 9/28/2025
Please keep the great work up through clean professional staff and facility at PRISMA health!!!
- 5 out of 5 starsReviewed on 9/4/2025
Give me a lollipop
- 3 out of 5 starsReviewed on 8/31/2025
Everything's fine. I don't think it could be any better.
- 5 out of 5 starsReviewed on 8/30/2025
Nothing to add, all was excellent
- 5 out of 5 starsReviewed on 8/29/2025
Other than the nurse not washing her hands I can't think of anything else. Everyone's so nice and polite. It's like my second family.
- 5 out of 5 starsReviewed on 8/24/2025
They did a great job there is nothing more I could have asked for.
- 5 out of 5 starsReviewed on 8/22/2025
You could make survey a little short. Some of the questions are the same.
- 5 out of 5 starsReviewed on 7/21/2025
Professional personnel. Dr. Humphrey nurses, and residents all have strong routine.
- 5 out of 5 starsReviewed on 7/21/2025
I don't really have any suggestions My Dr and his staff are really caring informative and on the money. I have a great respect for Dr. Humphrey and All his team.
- 5 out of 5 starsReviewed on 7/18/2025
Everything was done great already. (Smile)
- 5 out of 5 starsReviewed on 7/11/2025
The front desk people When you come in they take their time to handle business of checking you in
- 5 out of 5 starsReviewed on 7/9/2025
Everything was excellent
- 5 out of 5 starsReviewed on 7/6/2025
No concerns. I really appreciate and likey doctor, Dr. Mark Humphrey.
- 5 out of 5 starsReviewed on 7/6/2025
I have no complaints I've been with this doctor office for a long time
- 5 out of 5 starsReviewed on 6/12/2025
Nothing !!!,everything is Great!!!
- 5 out of 5 starsReviewed on 6/5/2025
No complaints. Keep doing what you're doing.
- 5 out of 5 starsReviewed on 6/2/2025
Everything was perfect.
- 5 out of 5 starsReviewed on 5/31/2025
Everything was excellent
- 5 out of 5 starsReviewed on 5/31/2025
I have no input. Everyone was on point. Thanks a bunch.
- 5 out of 5 starsReviewed on 4/27/2025
No changes needed.